Application
Western blot analysis of BRD7 expression in non-transfected: (A) and human BRD7 transfected: (B) 293Twhole cell lysates.| Product Name | BRD7 Antibody (H-77) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | BRD7 (bromodomain containing protein 7), also known as BP75 (75 kDa bromodomain protein), NAG4 or CELTIX1, is a 651 amino acid transcription regulation factor that contains one bromodomain and is expressed in liver, pancreas, intestines, kidney and cerebellum. Localizing to the nucleus, BRD7 plays an important role in cell cycle progression, signal-dependent gene expression and cell growth. BRD7 functions as a tumor suppressor, as is suggested by its apparent suppressive role on nasopharyngeal carcinoma (NPC) cell growth when overexpressed. Specifically, BRD7 negatively regulates the expression of cell cycle related proteins such as cyclin D1 and E2F-3, thereby inhibiting the G1-S progression. BRD7 also interacts with the centrosome associated protein BLOS2 and this BRD7-BLOS2 interaction inhibits the transcriptional suppression activity of BRD7 on various target genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BRD7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 397-473 mapping within an internal region of BRD7 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 397-473 mapping within an internal region of BRD7 of human origin |
| Entrez Gene | 29117 |
|---|
Application
Western blot analysis of BRD7 expression in non-transfected: (A) and human BRD7 transfected: (B) 293Twhole cell lysates.| Application Notes | recommended for detection of BRD7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
