Application
Western blot analysis of NDUFA10 expression in Jurkat (A) and HeLa (B) whole cell lysates and mouse heart (C) and mouse kidney (D) tissue extracts.| Product Name | NDUFA10 Antibody (H-110) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | NDUFA10 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10), also known as CI-42KD, is a 355 amino acid protein that localizes to the mitochondrial matrix and functions as an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase complex I. Complex I plays an important role in the transfer of electrons from NADH to the respiratory chain, a process that is essential for cellular respiration. NDUFA10 uses FAD as a cofactor and works in conjunction with other proteins to mediate complex I function and to ensure the proper transfer of electrons within the respiratory chain. The gene encoding NDUFA10 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alström syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NDUFA10 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 138-247 mapping within an internal region of NDUFA10 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 138-247 mapping within an internal region of NDUFA10 of human origin |
| Entrez Gene | 4705 |
|---|
Application
Western blot analysis of NDUFA10 expression in Jurkat (A) and HeLa (B) whole cell lysates and mouse heart (C) and mouse kidney (D) tissue extracts.| Application Notes | recommended for detection of NDUFA10 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
