Growth arrest specific proteins, including Gas 1, Gas 6 and Gas 7, are activated in quiescent cells. Gas 7 plays a role in neurite differentiation in cultured mouse cerebellar neurons and PC-12 cells, which makes it a potential therapeutic target to promote the re-establishment of neuronal connections in the injured or disease brain. The gene encoding human Gas7 maps to chromosome 17p13.1, which can translocate with MLL to form MLL-GAS7 fusion products. The Gas7 protein is expressed as three isoforms, a, b, and c, which are differentially expressed in all brain subregions.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of Gas7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 177-476 mapping at the C-terminus of Gas7 of human origin
Tissue Specificity
epitope corresponding to amino acids 177-476 mapping at the C-terminus of Gas7 of human origin
Western blot analysis of Gas7 expression in Jurkat whole cell lysate.
Application Notes
recommended for detection of Gas7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.