Application
Western blot analysis of Bcl-7b expression in non-transfected: (A) and human Bcl-7b transfected: (B) 293 whole cell lysates.| Product Name | Bcl-7b Antibody (P-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Bcl-7b (B-cell CLL/lymphoma 7B) is a 202 amino acid protein that exists as multiple alternatively spliced isoforms and belongs to the Bcl-7 family. Expressed ubiquitously, Bcl-7b is thought to play a role in the development and progression of lung tumors, suggesting a possible role in cell cycle or apoptotic control. Haploinsufficiency of the Bcl-7b gene is associated with the pathogenesis of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS). Additionally, Bcl-7b may cause an allergic reaction in humans, specifically by binding to IgE in atopic dermatitis patients and functioning as an autoantigen. The gene encoding Bcl-7b maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Bcl-7b of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with Bcl-7a or Bcl-7c also reactive with additional species, including canine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of Bcl-7b of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of Bcl-7b of human origin |
| Entrez Gene | 9275 |
|---|
Application
Western blot analysis of Bcl-7b expression in non-transfected: (A) and human Bcl-7b transfected: (B) 293 whole cell lysates.| Application Notes | recommended for detection of Bcl-7b of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with Bcl-7a or Bcl-7c also reactive with additional species, including canine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
