| Product Name | LASS5 Antibody (H-45) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 151-195 mapping within an internal region of LASS5 of human origin |
| Modification Notes | The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS5, also called TRH4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. On the luminal side of the endoplasmic reticulum membrane, the N-terminal asparagine residue is glycosylated. Functioning as a bona fide (dihydro)ceramide synthase, LASS5 increases the levels of short ceramide species, such as C14:0- and C16:0-ceramides as well as those selectively enriched in palmitic acid. LASS5 is the most abundantly expressed longevity assurance homolog in lung epithelia where it functions as a regulator of PtdCho metabolism. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS5 can increase ceramide levels and partially correct growth and apoptosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LASS5 of h, m and, to a lesser extent, rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 151-195 mapping within an internal region of LASS5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 151-195 mapping within an internal region of LASS5 of human origin |
| Application Notes | recommended for detection of LASS5 of h, m and, to a lesser extent, rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
