| Product Name | TIM-3 Antibody (H-191) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 111-301 mapping at the C-terminus of TIM-3 of human origin |
| Modification Notes | CD4+ T helper lymphocytes can be divided into types 1(Th1) and 2 (Th2) on the basis of their cytokine secretion patterns.Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions. Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. T cell Ig- and Mucin-domain-containing molecules (TIMs) are a family of molecules expressed on T cells. TIM-3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. TIM-3 binds galectin-9, thereby inducing apoptosis of Th1 cells. This interaction with galectin-9 also stimulates the phosphorylation of Tim-3 on residue Y265 by the interleukin-inducible T cell kinase, Emt. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TIM-3 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 111-301 mapping at the C-terminus of TIM-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 111-301 mapping at the C-terminus of TIM-3 of human origin |
| Entrez Gene | 84868 |
|---|
| Application Notes | recommended for detection of TIM-3 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
