| Product Name | mPRβ Antibody (H-79) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-79 mapping at the N-terminus of mPRβ of human origin |
| Modification Notes | The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways. Five distinct groups, designated å, ∫, ©, ∂ and ´, comprise the mPR gene family. mPRå, also designated progestin and adipoQ receptor family member VII (PAQR7), consists of an extracellular N-terminus, an intracellular C-terminus and seven transmembrane domains. mPRå is expressed in ovary, testis, placenta, uterus and bladder. mPR∫, or progestin and adipoQ receptor family member VIII (PAQR8), consists of eight putative transmembrane regions and an intracellular N-terminus that contains a leucine-rich motif. mPR∫ is a 354 amino acid protein expressed in brain and spinal cord. Both mPRå and mPR∫ may be G protein-coupled receptors and may be involved in oocyte maturation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of mPRβ (Membrane progestin receptor beta) of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-79 mapping at the N-terminus of mPRβ of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-79 mapping at the N-terminus of mPRβ of human origin |
| Entrez Gene | 85315 |
|---|
| Application Notes | recommended for detection of mPRβ (Membrane progestin receptor beta) of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
