| Product Name | CEP290 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1441-1740 mapping within an internal region of CEP290 of human origin |
| Modification Notes | Centrosomes are the major microtubule-organizing centers of mammalian cells. They are composed of a centriole pair and surrounding microtubule-nucleating material, termed pericentriolar material (PCM). Bipolar mitotic spindle assembly relies on two intertwined processes: centriole duplication and centrosome maturation. Failure to properly orchestrate centrosome duplication and maturation is subsequently linked to spindle defects, which can result in aneuploidy and promote cancer progression. The CEP290 (centrosomal protein of 290 kDa) gene encodes a protein of 2,479 amino acids that activates CREB-2-mediated transcription. Specifically, CEP290 ensures the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells. Mutations in the CEP290 gene have been identified in several diseases, including Joubert syndrome type 5 (JBTS5), Senior-Løken syndrome type 6 (SLSN6), Leber congenital amaurosis type 10 (LCA10) and Meckel syndrome type 4 (MKS4). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CEP290 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1441-1740 mapping within an internal region of CEP290 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1441-1740 mapping within an internal region of CEP290 of human origin |
| Entrez Gene | 80184 |
|---|
| Application Notes | recommended for detection of CEP290 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
