| Modification Notes |
The apolipoprotein L gene family maps to a region on chromosome 22 and encodes six highly homologous proteins, designated apoL-I, apoL-II, apoL-III, apoL-IV, apoL-V and apoL-VI, all of which function as components of plasma lipoproteins. ApoL-VI (apolipoprotein L-VI), also known as APOL6, is a 343 amino acid protein that localizes to the cytoplasm and belongs to the apolipoprotein L family. Expressed in a variety of tissues, including liver, heart, uterus, spleen, colon, spinal cord, placenta, prostate and mammary gland, apoL-VI is thought to affect the movement of lipids in the cytoplasm and may allow the binding of lipids to organelles. Overproduction of apoL-VI induces apoptosis, suggesting that apoL-VI may also be involved in tumor progression. Like other members of the apolipoprotein L family, apoL-VI is thought to be involved in the development of schizophrenia. |