| Product Name | Myoferlin Antibody (H-111) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 88-198 mapping near the N-terminus of Myoferlin of human origin |
| Modification Notes | Myoferlin, also known as Fer-1-like protein 3, is a member of the ferlin family of proteins and is structurally similar to dysferlin. It is a type II transmembrane protein with a single transmembrane domain very near the C-terminus, an SH3 domain and six C2 domains in the C-terminus (designated C2A-C2F). Myoferlin is predominantly expressed in cardiac and skeletal muscle and it localizes to the nuclear and plasma membranes. The C2 domains of Myoferlin may be involved in calcium-mediated membrane fusion events suggesting that Myoferlin may play a role in membrane regeneration and repair. Myoferlin is also responsible for regulating the stability and signaling of Flk-1, the VEGF receptor-2. The loss of Myoferlin prevents proliferation, migration and the release of nitric oxide (NO) in response to VEGF. In addition, Myoferlin may be implicated in various types of muscular dystrophy and cardiomyopathy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Myoferlin of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 88-198 mapping near the N-terminus of Myoferlin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 88-198 mapping near the N-terminus of Myoferlin of human origin |
| Entrez Gene | 26509 |
|---|
| Application Notes | recommended for detection of Myoferlin of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
