Application
Western blot analysis of LAPTM5 expression in P815 whole cell lysate.| Product Name | LAPTM5 Antibody (H-178) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 155-262 mapping at the C-terminus of LAPTM5 of human origin |
| Modification Notes | Lysosomal-associated transmembrane protein 5 (LAPTM5) is a 262 amino acid protein belonging to the LAPTM4/LAPTM5 transporter family. The LAPTM5 protein is highly expressed in immune cells and contains three PY motifs (L/PPxY) and a ubiquitin-interacting motif, both of which facilitate the interaction of LAPTM5 with other proteins. LAPTM5 modulates surface T cell antigen receptor (TCR) expression and activation by specifically binding to CD3Ω and promoting its degradation without affecting other CD3 proteins. The gene encoding LAPTM5 resides within the chromosomal band 1p34-36, a commonly rearranged locus in several types of cancers. Subsequently, loss of LAPTM5 expression may play an important role in the progression of human multiple myeloma (MM). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LAPTM5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 155-262 mapping at the C-terminus of LAPTM5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 155-262 mapping at the C-terminus of LAPTM5 of human origin |
| Entrez Gene | 7805 |
|---|
Application
Western blot analysis of LAPTM5 expression in P815 whole cell lysate.| Application Notes | recommended for detection of LAPTM5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
