Application
Western blot analysis of ALR expression in non-transfected: (A) and mouse ALR transfected: (B) 293T whole cell lysates.| Product Name | ALR Antibody (FL-205) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-205 representing full length ALR of human origin |
| Modification Notes | ALR (augmenter of liver regeneration), also called Erv1-like growth factor, hepatopoietin (HPO) or hepatic regenerative stimulation substance (HSS), is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase expressed in various tissues. ALR exists as a homodimer and belongs to the Erv1/ALR family of proteins. This family can be found in higher and lower eukaryotes. ALR has two forms: a cytosolic form and a nuclear form. The nuclear form regulates the transcriptional activity of AP-1. The cytosolic form plays a role in the biogenesis of Fe/S proteins and contributes to cellular iron homeostasis. In addition, ALR induces the expression of S-adenosylmethionine decarboxyl-ase and ornithine decarboxylase (ODC), which each play an important role in the synthesis of polyamines. Through stimulation of polyamine synthesis, ALR heavily contributes to the regulation of the different stages of liver regeneration. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ALR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-205 representing full length ALR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-205 representing full length ALR of human origin |
| Entrez Gene | 2671 |
|---|
Application
Western blot analysis of ALR expression in non-transfected: (A) and mouse ALR transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of ALR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
