Application
Western blot analysis of UROS expression in mouse thyroid tissue extract.| Product Name | UROS Antibody (M-265) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-265 representing full length UROS of mouse origin |
| Modification Notes | Uroporphyrinogen-III synthase (UROS), also designated hydroxymethylbilane hydrolyase, is a 265-amino acid ubiquitously expressed protein that is predominantly found in skeletal muscle, heart muscle, the caudate nucleus, and the amygdala. UROS is the fourth enzyme in the human heme biosynthetic pathway and is responsible for the conversion of hydroxymethylbilane to the cyclic tetrapyrrole, uroporphyrinogen III. UROS is a monomer involved in pophyrin biosynthesis by the Shemin pathway. Defects in the UROS gene can cause molecular lesions that lead to the autosomal recessive Gunther disease, also known as congenital erythropoietic porphyria (CEP). CEP is characterized by accumulation of uroporphyrin I in the bone marrow, peripheral blood, and other organs, often causing death early in adult life. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Uroporphyrinogen-III synthase (UROS) of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-265 representing full length UROS of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-265 representing full length UROS of mouse origin |
| Entrez Gene | 22276 |
|---|
Application
Western blot analysis of UROS expression in mouse thyroid tissue extract.| Application Notes | recommended for detection of Uroporphyrinogen-III synthase (UROS) of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
