| Product Name | TOPORS Antibody (H-127) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 251-377 mapping within an internal region of TOPORS of human origin |
| Modification Notes | TOPORS (topoisomerase I binding, arginine/serine-rich), also known as LUN, RP31, P53BP3 or TP53BPL, is a 1,045 amino acid protein that contains one RING-type zinc finger and localizes to discrete nuclear foci. Expressed in a variety of tissues with highest expression in testis, TOPORS functions as a ubiquitin E3 ligase that, via its RING domain, can ubiquitinate proteins such as p53, thereby targeting them for proteasomal degradation. TOPORS expression can be induced by genotoxic agents (compounds that damage DNA), such as camptothecin and cisplatin, suggesting an important role for TOPORS in DNA damage repair pathways. In addition, TOPORS levels are decreased in lung and colon cancers, implicating TOPORS as a possible tumor suppressor. Defects in the gene encoding TOPORS are the cause of retinitis pigmentosa type 31 (RP31), a degenerative disease characterized by a loss of peripheral and, eventually, central vision. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TOPORS of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 251-377 mapping within an internal region of TOPORS of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 251-377 mapping within an internal region of TOPORS of human origin |
| Entrez Gene | 10210 |
|---|
| Application Notes | recommended for detection of TOPORS of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
