Application
Western blot analysis of BSPII expression in CCD-1064Sk whole cell lysate.| Product Name | BSPII Antibody (H-157) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 161-317 mapping at the C-terminus of BSPII of human origin |
| Modification Notes | BSPII (bone sialoprotein II), also known as IBSP (integrin-binding sialoprotein), BSP (bone sialoprotein), BNSP or SP-II, is a secreted acidic glycosylated, sulfated and phosphorylated protein that is synthesized by osteoblasts, osteocytes, osteoclasts, hypertrophic chondroctyes and other skeletal-associated cell types. BSPII is a major structural protein in bone matrix and makes up approximately 12% of the noncollagenous proteins in human bone. Noncollagenous proteins are believed to function in the regulation of bone mineralization. BSPII is capable of nucleating hydroxyapatite crystal formation and, therefore, is thought to play an important role in initial mineralization of bone, cementum and dentin. Belonging to the SIBLING family of proteins, BSPII contains an RGD sequence which recognizes the vitronectin receptor Integrin åV and may participate in mediating cell attachment. In addition, BSPII is expressed in various cancers, including lung, thyroid, breast and prostate cancers. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BSPII of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 161-317 mapping at the C-terminus of BSPII of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 161-317 mapping at the C-terminus of BSPII of human origin |
| Entrez Gene | 3381 |
|---|
Application
Western blot analysis of BSPII expression in CCD-1064Sk whole cell lysate.| Application Notes | recommended for detection of BSPII of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
