| Modification Notes |
The SRR1 family of proteins are involved in regulating SOX2 expression during neurodevelopment and are active in neural stem cells. SRRD, also known as SRR1-like protein, SRR1 domain-containing protein or SRR1L, is a 339 amino acid protein belonging to the SRR1 family. SRRD may function in circadian clock input pathways and biological rhythms. The gene encoding SRRD maps to human chromosome 22q12.1. Chromosome 22 houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. |