| Product Name | TBKBP1 Antibody (E-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of TBKBP1 of human origin |
| Modification Notes | TBKBP1 (TBK1 binding protein 1), also known as SINTBAD, is a 615 amino acid adaptor protein that binds to TBK1 (TANK binding kinase) and IKK-i (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon). Involved in innate antiviral immunity and the TNFå /NF˚B pathway, TBKBP1 exists as a ubiquitously expressed homodimer found at highest levels in ovary. Lower levels of TKBP1 are found in brain, testis, lung, heart, kidney, liver and smooth muscle. TBKBP1 exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 17q21.32. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes, including two key tumor suppressor genes, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TBKBP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of TBKBP1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of TBKBP1 of human origin |
| Entrez Gene | 9755 |
|---|
| Application Notes | recommended for detection of TBKBP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
