Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes and bile duct cells.| Product Name | TRPM6 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1225-1524 mapping within an internal region of TRPM6 of human origin |
| Modification Notes | Transient receptor potential ion channels (TRPC) are a superfamily of six transmembrane segment-spanning gated cation channels. TRP subtypes mediate store-operated Ca2+ entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. TRP ion channels influence calcium-depletion-induced calcium influx processes in response to chemo-, mechano- and osmo-regulatory events. TRPM6 (transient receptor potential cation channel, subfamily M, member 6), also known as HSH, HMGX, HOMG, CHAK2 or HOMG1, is a 2022 amino acid multi-pass membrane protein that is highly expressed in kidney and colon. An essential ion channel and a serine/threonine-protein kinase, TRPM6 is crucial for magnesium homeostasis and has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TRPM6 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1225-1524 mapping within an internal region of TRPM6 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1225-1524 mapping within an internal region of TRPM6 of human origin |
| Entrez Gene | 140803 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes and bile duct cells.| Application Notes | recommended for detection of TRPM6 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
