Application
Western blot analysis of TMC2 expression in HeLa whole cell lysate.| Product Name | TMC2 Antibody (F-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within a cytoplasmic domain of TMC2 of human origin |
| Modification Notes | TMC2 (transmembrane channel-like 2), also known as transmembrane cochlear-expressed protein 2, is a 906 amino acid multi-pass membrane protein belonging to the TMC family of proteins. Expressed in fetal cochlea, TMC2 is essential for normal auditory function and may be necessary for proper function of cochlear hair cells. TMC2 exists as three alternatively spliced isoforms that are encoded by a gene located on human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TMC2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with isoform TMC2-3 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within a cytoplasmic domain of TMC2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within a cytoplasmic domain of TMC2 of human origin |
| Entrez Gene | 117532 |
|---|
Application
Western blot analysis of TMC2 expression in HeLa whole cell lysate.| Application Notes | recommended for detection of TMC2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with isoform TMC2-3 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
