| Product Name | Porimin Antibody (M-125) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 71-195 mapping at the C-terminus of Porimin of mouse origin |
| Modification Notes | Various death signals trigger cell death mediated by distinct pathways, including apoptosis and cytolysis, or oncosis. Oncosis is characterized by organelle and cell swelling, vacuolization and an increase in membrane permeability. Porimin is a 189 amino acid, keratinocyte-associated, pro-oncosis cell surface receptor that induces membrane injury. Porimin is a member of the cell membrane-associated Mucin family, characterized by the many O-linked and seven N-linked glycosylation sites on the extracellular domain. All tissues express Porimin except for ovary; it is highly expressed in colorectal adenocarcinoma and lung carcinoma. Porimin is a single-pass membrane protein that causes oncotic cell death by rapidly mediating pore formation on the plasma membrane. Porimin-mediated cell death is usually preceded by cell aggregation and the appearance of membrane blebs. Porimin may also play a role in the inhibition of cell adhesion. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Porimin of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 71-195 mapping at the C-terminus of Porimin of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 71-195 mapping at the C-terminus of Porimin of mouse origin |
| Entrez Gene | 71929 |
|---|
| Application Notes | recommended for detection of Porimin of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
