| Product Name | RNase HII-B Antibody (E-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of RNase HII-B of human origin |
| Modification Notes | RNase HII is a heterotrimeric enzyme complex responsible for the degradation of RNA found in RNA:DNA hybrids and is composed of one catalytic subunit and two non-catalytic subunits. RNase HII-B (ribonuclease H2, subunit B), also known as RNASEH2B, DLEU8, AGS2, FLJ11712 or Aicardi-Goutieres syndrome 2 protein, is one of the non-catalytic subunits of the RNase HII complex. While ubiquitously expressed, RNase HII-B localizes to the nucleus and is 312 amino acids long. Multiple natural transcript variants exist for the RNase HII-B gene. RNase HII-B is likely involved in the removal of RNA primers of lagging strand Okazaki fragments during DNA replication. Defects in the gene encoding RNase HII-B, which maps to human chromosome 13q14.1, are the cause of Aicardi-Goutieres syndrome type 2 (AGS2), an autosomal recessive neurological disorder characterized by leukodystrophy, cerebral atrophy, intracranial calcifications and chronic cerebrospinal fluid (CSF) lymphocytosis. Patients affected by AGS2 have severe neurological dysfunctions and often die in early childhood. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of RNase HII-B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of RNase HII-B of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of RNase HII-B of human origin |
| Entrez Gene | 79621 |
|---|
| Application Notes | recommended for detection of RNase HII-B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
