| Product Name | AHI1 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 601-897 mapping within an internal region of AHI1 of human origin |
| Modification Notes | AHI1 (Abelson helper integration site 1), also known as ORF1, AHI-1, JBTS3 or Jouberin, is a 1196 amino acid signaling protein that is expressed in the brain, specifically in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles . AHI1 contains seven WD repeats, an SH3 domain, and several SH3-binding sites and is critical for both cerebellar and cortical development. Mutations of AHI1 are associated with Joubert syndrome (JS), an autosomal recessive disorder characterized by hypotonia, ataxia, mental retardation, altered respiratory pattern, abnormal eye movements and a brain malformation. Considered a novel oncogene, AHI1 is highly deregulated in Chronic myeloid leukemia (CML). Three isoforms exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of AHI1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 601-897 mapping within an internal region of AHI1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 601-897 mapping within an internal region of AHI1 of human origin |
| Entrez Gene | 54806 |
|---|
| Application Notes | recommended for detection of AHI1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
