| Product Name | PDE6G/H Antibody (FL-87) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-87 representing full length PDE6G of human origin |
| Modification Notes | Phosphodiesterases (PDEs, also designated cyclic nucleotide phosphodiesterases) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP), as they are responsible for hydrolyzing cAMP to 5'AMP. PDE6G, also designated phosphodiesterase 6G cGMP-specific rod gamma, is an oligomer composed of two catalytic chains (å and ∫), an inhibitory chain (©) and an ∂ chain. PDEG6G functions in the processes of transmission and amplification of the visual signal. A mutation in the rod PDE-© gene desensitizes and delays murine rod photoreceptors. PDE6H, also designated phosphodiesterase 6H cGMP-specific cone gamma, is a tetramer composed of two catalytic chains (å and ∫), and two inhibitory chains (©). It functions similarly to PDE6H in vision processes. Defects of the PDE6H gene cause retinal cone dystrophy 3 (rcd3), also designated cone dystrophy with night blindness and supernormal rod responses. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PDE6G and PDE6H of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-87 representing full length PDE6G of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-87 representing full length PDE6G of human origin |
| Application Notes | recommended for detection of PDE6G and PDE6H of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
