| Modification Notes |
HIVEP1 (human immunodeficiency virus type I enhancer binding protein 1), also known as CIRIP (cirhin interaction protein), MBP-1 (major histocompatibility complex binding protein 1), ZNF40, CRYBP1 (åA-crystallin binding protein 1) or PRDII-BF1 (positive regulatory domain II binding factor 1), is a large DNA-binding protein that belongs to the ZAS family. HIVEP1 contains a pair of C2H2 zinc fingers with a serine/threonine-rich sequence and an acidic-rich region, as well as a ZAS domain. It is ubiquitously expressed and is directly involved in the transcriptional regulation of a variety of genes. There are homologs of this gene in D. melanogaster and C elegans. In humans, HIVEP1 interacts with the IFN-∫ promoter and enhancer in the HIV-1 long terminal repeat. It specifically binds to the DNA sequence 5’-GGGACTTTCC-3’. Various isoforms of HIVEP1 exist due to alternative splicing events. HIVEP1 may also participate in T-cell activation. |