| Product Name | TRM61 Antibody (H-134) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 13-146 mapping near the N-terminus of TRM61 of human origin |
| Modification Notes | TRM61 (tRNA m(1)A58 methyltransferase subunit TRM61), also known as GCD14, is one of two subunits (the other being TRM6) that function as heterotetramers to comprise the tRNA m(1)A58 methyltransferase. The tRNA m(1)A58 methyltransferase plays a role in tRNA modification and is specifically responsible for the formation of 1-methyladenosine. 1-methyladenosine is a modified nucleoside found at position 58 in tRNA and is required for maintaining the stability of initiator methionine tRNA (tRNAiMet) which is directly involved in the initiation of protein synthesis. This implies that TRM61 is crucial for proper tRNA structure and function. Mutations in the gene encoding TRM61 which cause structural changes in the substrate-binding pocket of tRNA m(1)A58 methyltransferase can lead to instability of tRNAiMet. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TRM61 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 13-146 mapping near the N-terminus of TRM61 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 13-146 mapping near the N-terminus of TRM61 of human origin |
| Entrez Gene | 115708 |
|---|
| Application Notes | recommended for detection of TRM61 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
