Application
Western blot analysis of FAM86A/B2/C expression in HeLa whole cell lysate.| Product Name | FAM86A/B2/C Antibody (E-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier. FAM86A is a 330 amino acid protein that belongs to the FAM86 family and is encoded by a gene located on human chromosome 16. Also members of the FAM86 family, FAM86B2 and FAM86C are encoded by genes that map to human chromosomes 8 and 11, respectively. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIPWB |
| recommended for detection of FAM86A, FAM86B2 and FAM86C of human and, to a lesser extent, mouse origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of FAM86B2 of human origin |
|---|---|
| Molecular Weight(MW) | 37kDa |
| Tissue Specificity | epitope mapping within an internal region of FAM86B2 of human origin |
Application
Western blot analysis of FAM86A/B2/C expression in HeLa whole cell lysate.| Application Notes | recommended for detection of FAM86A, FAM86B2 and FAM86C of human and, to a lesser extent, mouse origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
