| Modification Notes |
TPIP, also known as TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2), phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2, lipid phosphatase TPIP, or TPTE and PTEN homologous inositol lipid phosphatase, is a 522 amino acid multi-pass membrane protein containing a C2 tensin-type domain, and one phosphatase tensin-type domain. Localizing to the endoplasmic reticulum membrane, TPIP exists as four alternatively spliced isoforms, designated TPIP-gamma, TPIP-2, TPIP-alpha, and TPIP-beta. TPIP-beta, which lacks a transmembrane domain and contains a truncated CS domain, localizes to cytoplasm and is testis specific. TPIP-alpha is expressed in testis, brain and stomach and shows a high degree of sequence conservation with PTEN as well as TPTE. The gene encoding TPIP maps to human chromosome 13q12.11. |