| Product Name | LASS2 Antibody (O-24) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of LASS2 of mouse, rat and human origin by WB, IP and ELISA |
| Modification Notes | The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins involved in sphingolipid synthesis have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6). LASS2 is a 380 amino acid multi-pass membrane protein expressed in kidney, liver, brain, heart, placenta and lung. LASS2 suppresses the growth of cancer cells and is involved in sphingolipid synthesis. Overproduction of LASS2 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. The N-terminal asparagine residue serves as a site for glycosylation on the luminal side of the endoplasmic reticulum membrane. LASS2 interacts with several membrane-associated receptors or transporters including ASGPR1, ASGPR2 and OCT1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of LASS2 of mouse rat and human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of LASS2 of mouse, rat and human origin by WB, IP and ELISA |
| Entrez Gene | 29956 |
|---|
| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
