| Modification Notes |
The family of P-type adenosine triphosphates (ATPases), which are phosphorylated in their intermediate state, are involved in the active transport of charged substrates across biological membranes. Members of this family are ubiquitous integral membrane proteins and can be divided into 5 major groups consisting of several subfamilies each. The P-type ATPase Type IV family members are characterized as phospholipid pumps and are then divided into 6 classes determined by sequence similarity. ATP8A2 (ATPase class I type 8A member) is a 1,148 amino acid protein that is strongly expressed in brain, testis and heart. ATP8A2 is a multi-pass transmembrane protein that uses ATP to maintain ion gradients across the cell membrane and may possess some aminophospholipid translocase activity. There are two named isoforms of ATP8A2 which are a result of alternative splicing events. |