Application
Western blot analysis of NURIM expression in non-transfected: (A) and mouse NURIM transfected: (B) 293T whole cell lysates.| Product Name | NURIM Antibody (C-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of NURIM of human origin |
| Modification Notes | NURIM, also known as NRM or NRM29, is a 262 amino acid multi-pass membrane protein that localizes to the inner membrane of the nucleus. Existing as multiple alternatively spliced isoforms, NURIM is thought to possess enzymatic functions that may play a role in nuclear envelope (NE) dynamics. The gene encoding NURIM maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NURIM isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with NURIM isoforms 3, 4 or 5 also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of NURIM of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of NURIM of human origin |
| Entrez Gene | 11270 |
|---|
Application
Western blot analysis of NURIM expression in non-transfected: (A) and mouse NURIM transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of NURIM isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with NURIM isoforms 3, 4 or 5 also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
