| Product Name | GGTL3 Antibody (L-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Glutathione is a tripeptide electron donor that functions as an antioxidant, protecting cells from toxins by reducing disulfide bonds during oxidative stress. The metabolism of Glutathione requires a variety of enzymes, such as GGT1, GGT2, GGT5, GGTLC2 and GGTL3. GGTL3, also known as GGT7 (©-glutamyltransferase 7), GGT4 or GGTL5, is a 662 amino acid single-pass type II membrane protein that belongs to the ©-glutamyltransferase family and is involved in the pathway of Glutathione metabolism. Expressed at low levels in multiple tissues, including lung, liver, heart, brain, testis and spleen, GGTL3 functions as a heterodimer of light and heavy chains that work together to cleave glutathione-conjugated peptides, thereby releasing an unconjugated protein. GGTL3 exists as multiple alternatively spliced isoforms and, via its catalytic activity, may be involved in the pathogenesis of lung cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of GGTL3 of human origin by WB, IF and ELISA non cross-reactive with GGTL3-2, GGTL3-B, or GGTL3-4 also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an extracellular domain of GGTL3 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an extracellular domain of GGTL3 of human origin |
| Entrez Gene | 2686 |
|---|
| Application Notes | recommended for detection of GGTL3 of human origin by WB, IF and ELISA non cross-reactive with GGTL3-2, GGTL3-B, or GGTL3-4 also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
