| Modification Notes |
TMEM55A (transmembrane protein 55A) is a 257 amino acid multi-pass membrane protein that localizes to both the lysosomal and the late endosomal membranes. Expressed ubiquitously, TMEM55A functions to catalyze the H2O-dependent hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate, thereby playing a crucial role in the degradation of phosphatidylinositol-4,5-bisphosphate. The gene encoding TMEM55A maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. |