Application
Western blot analysis of Rab L4 expression in non-transfected 293T: (A), human Rab L4 transfected 293T: (B) and HeLa (C) whole cell lysates.| Product Name | Rab L4 Antibody (S-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of Rab L4 of human origin |
| Modification Notes | The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies, all of which are thought to play an important role in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum (ER) to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab L4 (Rab, member RAS oncogene family-like 4) is a 186 amino acid protein that belongs to the Rab family of guanine nucleotide binding proteins, suggesting a role in protein transport. The gene encoding Rab L4 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Rab L4 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other Rab family members also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of Rab L4 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of Rab L4 of human origin |
| Entrez Gene | 11020 |
|---|
Application
Western blot analysis of Rab L4 expression in non-transfected 293T: (A), human Rab L4 transfected 293T: (B) and HeLa (C) whole cell lysates.| Application Notes | recommended for detection of Rab L4 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other Rab family members also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
