Application
Western blot analysis of Torsin3A expression in non-transfected 293T: (A), human Torsin3A transfected 293T: (B) and U-87 MG (C) whole cell lysates.Application
Western blot analysis of Torsin3A expression in non-transfected: (A) and human Torsin3A transfected: (B) 293T whole cell lysates.Application
Western blot analysis of Torsin3A expression in transfected 293T whole cell lysate.| Product Name | Torsin3A Antibody (T-23) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against Torsin3A of human origin |
| Modification Notes | Torsin3A (TOR3A), also known as ATP-dependent interferon-responsive protein (ADIR), is a 397 amino acid member of the clpA/clpB family of proteins. Localized to the cytoplasm and the endoplasmic reticulum, Torsin3A is most highly expressed in stomach, lymph nodes and salivary glands. Torsin3A contains a hydrophobic N-terminal sequence, an ATP binding domain and 8 putative phosphorylation sites. Highly homologous with TorsinA and TorsinB, Torsin3A is thought to be related to the AAA chaperone-like family of ATPases. Members of this family play a role in the assembly, disassembly and operation of a variety of protein complexes, confer increased tolerance to high temperature and promote specific proteolysis. Torsin3A is also referred to as an interferon responsive gene, as interaction with type 1 interferons (IFN-å and IFN-∫) cause a 5 to 40 fold increase in Torsin3A mRNA levels. Three isoforms of Torsin3A exist as a result of alternative splicing events, and isoform 2 is expressed exclusively in the placenta. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of Torsin3A of human and canine origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against Torsin3A of human origin |
|---|---|
| Tissue Specificity | raised against Torsin3A of human origin |
| Entrez Gene | 64222 |
|---|
Application
Western blot analysis of Torsin3A expression in non-transfected 293T: (A), human Torsin3A transfected 293T: (B) and U-87 MG (C) whole cell lysates.
Application
Western blot analysis of Torsin3A expression in non-transfected: (A) and human Torsin3A transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of Torsin3A expression in transfected 293T whole cell lysate.| Application Notes | recommended for detection of Torsin3A of human and canine origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
