| Product Name | ADAMTS-15 Antibody (H-135) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 781-915 mapping near the C-terminus of ADAMTS-15 of human origin |
| Modification Notes | ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of Thrombospondin type-1 (TSP 1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. ADAMTS-15 is a weak aggrecanase expressed in the fetal kidney and liver. It cleaves the interglobular domain of aggrecan, separating the G1 and G2 domains. In human breast carcinoma, low expression levels of ADAMTS-15 together with high expression levels of ADAMTS-8 is associated with a greater risk for recurrence and death. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ADAMTS-15 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 781-915 mapping near the C-terminus of ADAMTS-15 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 781-915 mapping near the C-terminus of ADAMTS-15 of human origin |
| Entrez Gene | 170689 |
|---|
| Application Notes | recommended for detection of ADAMTS-15 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
