Application
Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and membrane localization.| Product Name | VDUP1 Antibody (H-115) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-115 mapping at the N-terminus of VDUP1 of human origin |
| Modification Notes | The gene encoding vitamin D3 upregulated protein 1 (VDUP1) is upregulated by 1,25(OH)2D3 in response to various stresses, including ROS, UV and heat shock. The transcription factor HSF may be involved in this regulation. VDUP1 also functions as a natural antagonist of TRX, and displays tumor-suppressive activity by inducing cell cycle arrest at the G0/G1 phase. The presence of VDUP1 is required for CD122 expression and natural killer (NK) cell maturation, but its effect is minimal during the development of T and B cells. The gene encoding human VDUP1 maps to chromosome 1q21, and its protein product shows ubiquitous expression in various tissues and localizes to the cytoplasm. VDUP1 may also be a useful therapeutic target for melanoma. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of VDUP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-115 mapping at the N-terminus of VDUP1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-115 mapping at the N-terminus of VDUP1 of human origin |
| Entrez Gene | 10628 |
|---|
Application
Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and membrane localization.| Application Notes | recommended for detection of VDUP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
