| Product Name | PARC Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 2161-2460 mapping near the C-terminus of PARC of human origin |
| Modification Notes | The p53 tumor suppressor gene is altered in over 50% of human cancers. The p53 binding proteins 53BP1 and 53BP2 (Bbp) are tumor suppressors that bind to the site-specific central DNA-binding domain of wild type p53 in a conformation-dependent manner. Severe DNA damage can cause phosphorylation of p53 at position serine-46. This event triggers expression of p53AIP1 (apoptosis inducing protein), which contributes to subsequent events leading to programmed cell death. The protein PARC (p53 associated Parkin-like cytoplasmic protein) acts as a cytoplasmic anchor for p53 in unstressed cells, thereby regulating the localization and subsequent function of p53. The C-terminus of the PARC protein contains a RING-IBR-RING domain, which suggests it retains ubiquitin ligase activity, but PARC fails to promote degradation of p53. The gene encoding human PARC maps to chromosome 6p21.1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of p53-associated Parkin-like cytoplasmic protein of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 2161-2460 mapping near the C-terminus of PARC of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 2161-2460 mapping near the C-terminus of PARC of human origin |
| Entrez Gene | 23113 |
|---|
| Application Notes | recommended for detection of p53-associated Parkin-like cytoplasmic protein of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
