| Modification Notes |
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF589 (zinc finger protein 589), also known as SZF1 or stem cell zinc finger protein 1, is a 364 amino acid protein that plays a role in the differentiation of hematopoietic stem cells, and may at as a repressor of DNA binding-dependent transcription. ZNF589 belongs to the krueppel C2H2-type zinc-finger protein family, localizes to nucleus, and contains four C2H2-type zinc fingers and one KRAB domain. As a result of alternative splicing, three ZNF589 isoforms exist; while the expression of ZNF589 isoform 1 has not been fully characterized, isoform 2 (also known as SZF1-2) has been found to be ubiquitously expressed and isoform 3 (also known as SZF1-1) is only found in CD34+ cells. The gene encoding ZNF589 maps to human chromosome 3p21.31. |
