| Modification Notes |
The PAQR superfamily of receptors includes AdipoR1, AdipoR2, mPRå, mPR∫, mPR©, mPR∂, mPR´, PAQR3 and PAQR4, all of which encode functional receptors with a broad range of ligand specificities. The best characterized family members are AdipoR1 and AdipoR2, which regulate fatty acid oxidation and the uptake of glucose by adiponectin. Certain PAQR family members have been shown to specifically bind progesterone and mediate non-genomic effects. In yeast, since PAQR progeseterone-dependent signaling does not require heterotrimeric G-proteins, it is suspected that PAQRs may function as a novel class of G-protein coupled receptors. mPR´, also known as PAQR9 (progestin and adipoQ receptor family member 9), is a 377 amino acid multi-pass membrane protein that responds to progesterone binding. |