| Product Name | TRESK Antibody (H-92) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 224-315 mapping near the C-terminus of TRESK of human origin |
| Modification Notes | Potassium channels play an important role in cell excitability and plasticity. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. The family of potassium channels possessing two-pore loop domains consists of both inward and outwardly rectifying channels and includes THIK-1, THIK-2, TRESK, TALK-1 and TALK-2. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. TWIK-related spinal cord K+ (TRESK) is the most sensitive volatile anesthetic-activated channel in the family and may function to mediate the effects of inhaled anesthetics in the central nervous system in a manner that is sensitive to immunosuppressive drugs. TRESK is activated by the calcium signal from calcineurin, a calcium/calmodulin-dependent phosphatase, and is highly sensitive to zinc. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TRESK of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 224-315 mapping near the C-terminus of TRESK of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 224-315 mapping near the C-terminus of TRESK of human origin |
| Entrez Gene | 338567 |
|---|
| Application Notes | recommended for detection of TRESK of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
