Application
Western blot analysis of RANKL expression in non-transfected: (A) and human RANKL transfected: (B) 293 whole cell lysates.Application
Immunofluorescence staining of normal mouse heart frozen section showing membrane and cytoplasmic staining.Application
Western blot analysis of mouse recombinant RANK ligand.| Product Name | RANKL Antibody (FL-317) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 46-317 of RANKL (RANK ligand) of human origin |
| Modification Notes | Members of the tumor necrosis factor (TNF) receptor superfamily interact with signaling molecules of the TNF receptor-associated factor (TRAF) family to activate the NF˚B and JNK pathways. RANK (receptor activator of NF˚B) is a member of the TNFR family identified on dendritic cells. This type I membrane receptor is expressed in a broad range of tissues. The C-terminus of RANK is required for RANK to bind TRAF2, 5 and 6, and it is also necessary for stimulating NF˚B activation. The ligand for this receptor, RANKL (also designated TRANCE, OPGL or ODF), is a type II transmembrane protein expressed primarily in lymphoid tissues and T cell lines. RANKL appears to be an important regulator of T cells and osteoclasts. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| suitable control antibody: : sc-RANKL (h): CHO Lysate: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 46-317 of RANKL (RANK ligand) of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 46-317 of RANKL (RANK ligand) of human origin |
| Entrez Gene | 8600 |
|---|
Application
Western blot analysis of RANKL expression in non-transfected: (A) and human RANKL transfected: (B) 293 whole cell lysates.
Application
Immunofluorescence staining of normal mouse heart frozen section showing membrane and cytoplasmic staining.
Application
Western blot analysis of mouse recombinant RANK ligand.| Application Notes | suitable control antibody: : sc-RANKL (h): CHO Lysate: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
