Application
Western blot analysis of C8β expression in Hep G2 whole cell lysate.Application
Western blot analysis of C8β expression in human fetal liver tissue extract.Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human intestine tissue showing cytoplasmic localization.| Product Name | C8β Antibody (U-21) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against synthetic C8β peptide of human origin |
| Modification Notes | The complement cascade is a multi-protein system that functions to clear pathogens from an infected host. Part of the innate (unchanging) immune system, the complement cascade consists of proteins and inactive zymogens that are present in blood and are stimulated by one of several triggers. Once stimulated, the cascade relays amplified responses throughout the body, ultimately activating the cell-killing membrane attack complex which can insert itself into the cell membrane and cause the cell to lyse.C8∫ (complement component 8, beta polypeptide) is a 591 amino acid secreted protein that contains one EGF-like domain, one LDL-receptor class A domain, one MACPF domain and two TSP domains. Existing as a part of the membrane attack complex with C8å and C8©, C8∫ binds to the C5-7 complex and acts to catalyze the polymerization of C9. Defects in the gene encoding C8∫ are associated with complement C8 deficiency type II, a condition characterized by recurrent bacterial infections. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of C8β of human origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against synthetic C8&beta peptide of human origin |
|---|---|
| Tissue Specificity | raised against synthetic C8β peptide of human origin |
| Entrez Gene | 732 |
|---|
Application
Western blot analysis of C8β expression in Hep G2 whole cell lysate.
Application
Western blot analysis of C8β expression in human fetal liver tissue extract.
Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human intestine tissue showing cytoplasmic localization.| Application Notes | recommended for detection of C8β of human origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
