Application
Western blot analysis of Dopey-2 expression in MOLT-4 whole cell lysate.| Product Name | Dopey-2 Antibody (E-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of Dopey-2 of human origin |
| Modification Notes | Dopey-2, also known as C21orf5, is a 2,298 amino acid protein that is ubiquitously expressed with high levels found in the developing central nervous system where it is thought to play a role in protein trafficking between early endosomes and the late Golgi. Multiple isoforms of Dopey-2 exist due to alternative splicing events. The gene encoding Dopey-2 maps to human chromosome 21 and may be involved in the pathogenesis of Down syndrome. The smallest of the human chromosomes, chromosome 21 comprises about 1.5% of the human genome and contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimer's disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21. Translocations are found to occur between chromosome 21 and 8, and chromosome 21 and 12, in certain leukemias. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Dopey-2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with family member Dopey-1 also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of Dopey-2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of Dopey-2 of human origin |
| Entrez Gene | 9980 |
|---|
Application
Western blot analysis of Dopey-2 expression in MOLT-4 whole cell lysate.| Application Notes | recommended for detection of Dopey-2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with family member Dopey-1 also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
