Application
Western blot analysis of WDR12 expression in Jurkat whole cell lysate.| Product Name | WDR12 Antibody (B-21) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against WDR12 of human origin |
| Modification Notes | WD repeat containing protein 12 (WDR12), also known as YTM1 homolog, is a 423 amino acid protein that localizes to the nucleus. WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDR12, which contains 7 WD-repeats, has been characterized to form a stable complex with pescadillo and BOP1. This complex, named PeBoW, plays a critical role in the mammalian ribosome biogenesis pathway. A mutation in the gene encoding WDR12 leads to an inhibition of ribosomal RNA (rRNA) processing and triggers p53-dependent cell cycle arrest. Pescadillo, BOP1 and WDR12 expression has been shown to be upregulated by the oncogenic transcription factor c-Myc. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of WDR12 of mouse, rat, human and canine origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against WDR12 of human origin |
|---|---|
| Tissue Specificity | raised against WDR12 of human origin |
| Entrez Gene | 55759 |
|---|
Application
Western blot analysis of WDR12 expression in Jurkat whole cell lysate.| Application Notes | recommended for detection of WDR12 of mouse, rat, human and canine origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
