Application
Western blot analysis of DNASE2B expression in Hep G2 whole cell lysate.| Product Name | DNASE2B Antibody (S-22) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against DNASE2B of human origin |
| Modification Notes | DNase II is a ubiquitously expressed endonuclease that, in the absence of divalent cations, catalyzes DNA hydrolysis. DNASE2B (deoxyribonuclease II beta), also known as DLAD, is a 361 amino acid protein that shares structural and sequence similarity to DNase II. Expressed at high levels in salivary gland and eye tissues and at lower levels in prostate, lung and lymph node, DNASE2B localizes to the lysosome and functions to catalytically cleave nucleoside 3’-phosphates and 3’-phosphooligonucleotides. Via its endonucleolytic activity, DNASE2B hydrolyzes DNA under acidic conditions and plays a role in the degradation of nuclear DNA during lens differentiation within the eye. DNASE2B exists as two isoforms produced by alternative splicing events. While isoform one is found in tissues throughout the body, isoform two is expressed primarily in the lungs. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of DNASE2B of human origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against DNASE2B of human origin |
|---|---|
| Tissue Specificity | raised against DNASE2B of human origin |
| Entrez Gene | 58511 |
|---|
Application
Western blot analysis of DNASE2B expression in Hep G2 whole cell lysate.| Application Notes | recommended for detection of DNASE2B of human origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
