Application
Western blot analysis of Thrombospondin 5 expression in non-transfected: (A) and human Thrombospondin 5 transfected: (B) 293T whole cell lysates.| Product Name | Thrombospondin 5 Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 21-110 mapping near the N-terminus of Thrombospondin 5 of human origin |
| Modification Notes | Thrombospondin 5 (also designated THBS5, cartilage oligomeric matrix protein or COMP) is the fifth member of the Thrombospondin family of extracellular matrix proteins. The Thrombospondin family share overall homology, with significant homology in their carboxy-terminal globular domains. They all contain type 2 (epidermal growth factor-like) and type 3 (calmodulin-like) repeats in their central domains. The human COMP/THBS5 gene maps to chromosome 19p13.1. Thrombospondin 5 is expressed in all types of cartilage, tendon and vascular smooth muscle. Its localization in cartilage is developmentally regulated to the chondrocyte territorial and interterritorial matrix. Thrombospondin 5 also binds to Collagen Type I, II and IX in a zinc-dependent manner. Mutations in the COMP/THBS5 gene are associated with the human genetic disorders pseudoachondroplasia (PSACH) and some types of multiple epiphyseal dysplasia (MED). PSACH and MED are autosomal dominant chondrodysplasias, which cause mild to severe short-limb dwarfism and early-onset osteoarthritis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Thrombospondin 5 (also designated COMP) of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 21-110 mapping near the N-terminus of Thrombospondin 5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 21-110 mapping near the N-terminus of Thrombospondin 5 of human origin |
| Entrez Gene | 1311 |
|---|
Application
Western blot analysis of Thrombospondin 5 expression in non-transfected: (A) and human Thrombospondin 5 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of Thrombospondin 5 (also designated COMP) of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
