| Product Name | RASAL2 Antibody (H-48) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-48 mapping at the N-terminus of RASAL2 of human origin |
| Modification Notes | RASAL2 (Ras protein activator like 2), also known as nGAP, is a Ras GTPase-activating protein. RAS proteins cycle between an active guanosine-triphosphate (GTP) bound form and an inactive, guanosine-diphosphate (GDP) bound form. GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. RASAL2 functions in the Ras/MAPK/ERK signaling pathway. It contains a C2 domain, a PH domain and a Ras-GAP domain. The gene encoding RASAL2 is located on chromosome 1 within the prostate cancer susceptibility locus. This suggests that a mutation or defect in RASAL2 is implicated in carcinogenesis. Two transcript variants exist for RASAL2 due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Ras GTPase-activating protein nGAP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-48 mapping at the N-terminus of RASAL2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-48 mapping at the N-terminus of RASAL2 of human origin |
| Entrez Gene | 9462 |
|---|
| Application Notes | recommended for detection of Ras GTPase-activating protein nGAP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
