| Product Name | GRB10 Antibody (K-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of GRB10 of mouse origin |
| Modification Notes | Many growth factors function by binding receptors with intrinsic tyrosine kinase activity (1,2). Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and specific phosphotyrosine-containing receptor sequences (3,4). GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus (5,6). A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7 (6,7). GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly (7). GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor (7). Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2 (6,7). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of mouse and rat GRB10 and the human homolog GRB-IR by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of GRB10 of mouse origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of GRB10 of mouse origin |
| Entrez Gene | 2887 |
|---|
| Application Notes | recommended for detection of mouse and rat GRB10 and the human homolog GRB-IR by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
