| Product Name | TTK Antibody (H-130) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 712-841 of TTK of human origin |
| Modification Notes | Progression of cells through the cell cycle is regulated by variations in the levels and activities of a series of protein kinases as well as by oscillation in the levels of their regulatory subunits (i.e., cyclins). The full length sequence for a unique protein kinase of human origin, designated TTK, was cloned by screening a T cell expression library with anti-phosphotyrosine antibodies. Similarly, the mouse homolog of TTK was isolated from an embryonal carcinoma (EC) cell line by expression cloning. TTK/Esk are novel members of the serine-threonine/tyrosine family of protein kinases and are expressed in a broad range of proliferating human cells and tissues. TTK-Esk expression is reduced or absent in resting cells and in cells with a low proliferative index. When cells are induced to enter the cell cycle, levels of TTK mRNA, protein and kinase activity increase at the G1 to S phase of the cell cycle and peak in the G2 to M phase, suggesting that TTK/Esk may function as cell cycle regulatory components. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TTK of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 712-841 of TTK of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 712-841 of TTK of human origin |
| Entrez Gene | 7272 |
|---|
| Application Notes | recommended for detection of TTK of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
