| Product Name | Dok-3 Antibody (H-206) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 291-496 mapping at the C-terminus of Dok-3 of human origin |
| Modification Notes | Dok-1, Dok-2 and Dok-3 are members of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites (1-3). Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation (1). Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl (4). Dok-3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages (5). Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of Dok-3 (5). Upon phosphorylation, Dok-3 binds to 5’ inositol phosphatase SHIP and the protein tyrosine kinase Csk (5). Dok-3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells (5). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Dok-3 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 291-496 mapping at the C-terminus of Dok-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 291-496 mapping at the C-terminus of Dok-3 of human origin |
| Entrez Gene | 79930 |
|---|
| Application Notes | recommended for detection of Dok-3 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
